For Canadian men living with advanced prostate cancer that has spread to their bones, access to bone-targeted treatment may depend on where they live rather than on evidence-based standard of care.
For example, men who live in some provinces, such as Alberta, must pay for bone-targeted therapies out of their own pocket or through private insurance, but men living in Ontario or Quebec do not because the drug is covered for them.
When left untreated, cancer that has spread to the bone can lead to serious and debilitating complications that can cause pain, disability and even death. To prevent debilitating complications, it’s important to have access to the most appropriate bone-targeting treatment at the earliest sign of metastases when the agent can be most helpful.
Across Canada, bone-modifying agents for prostate cancer are covered through different mechanisms, such as hospitals, provincial drug plans, and cancer agencies. CCSN is advocating for wider access to bone-targeting agents in provinces where access is limited or where only one class of treatment is available. The following chart indicates which provinces provide coverage and where unreasonable coverage gaps continue to exist.
Province
|
denosumab
|
zoledronic acid
|
British Columbia
|
Covered (palliative only)
|
Covered (palliative only)
|
Saskatchewan
|
Covered
|
Covered
|
Alberta
|
Not covered
|
Not covered
|
Manitoba
|
Covered
|
Covered
|
Ontario
|
Covered
|
Covered
|
Quebec
|
Covered
|
Not covered
|
Newfoundland and Labrador
|
Not covered
|
Covered
|
New Brunswick
|
Covered
|
Covered
|
Nova Scotia
|
Covered
|
Covered
|
Prince Edward Island
|
Not covered
|
Not covered
|
Class: RANK Ligand Inhibitors
Denosumab is used for reducing the risk of developing cancer-related complications like broken bones and/or bone pain that need surgery or radiation. It’s administered as a single injection under the skin (subcutaneous) once every four weeks.
Class: Bisphosphonates
Zoledronic acid is indicated for the treatment of patients with documented bone metastases from solid tumours (including prostate cancer, breast cancer, lung cancer, renal cell carcinoma and other solid tumours) to prevent or delay potential complications from the bone lesions. It’s administered to patients through intravenous infusion (IV infusion).