{"id":6179,"date":"2017-07-19T14:51:57","date_gmt":"2017-07-19T14:51:57","guid":{"rendered":"https:\/\/survivornet.ca\/news\/cotellic-cobimetinib-quebec\/"},"modified":"2017-07-19T14:54:03","modified_gmt":"2017-07-19T14:54:03","slug":"cotellic-cobimetinib-quebec","status":"publish","type":"news","link":"https:\/\/survivornet.ca\/fr\/apprenez\/nouvelles\/cotellic-cobimetinib-quebec\/","title":{"rendered":"Cotellic (Cobim\u00e9tinib) dans Qu\u00e9bec"},"content":{"rendered":"<p><strong>COBIM\u00c9TINIB :<\/strong><\/p>\n<p>-en association avec le v\u00e9muraf\u00e9nib, pour le traitement de premi\u00e8re intention ou de deuxi\u00e8me intention \u00e0 la suite d\u2019un \u00e9chec \u00e0 une chimioth\u00e9rapie cytotoxique ou \u00e0 une immunoth\u00e9rapie ciblant le PD-1 ou le CTLA-4, d\u2019un m\u00e9lanome non r\u00e9s\u00e9cable ou m\u00e9tastatique pr\u00e9sentant une mutation BRAF V600, chez les personnes dont le statut de performance selon l\u2019ECOG est de 0 ou 1.<\/p>\n<p>L\u2019autorisation initiale est pour une dur\u00e9e maximale de 4 mois.<\/p>\n<p>Lors des demandes subs\u00e9quentes, le m\u00e9decin devra fournir la preuve d\u2019un effet clinique b\u00e9n\u00e9fique par l\u2019absence de progression de la maladie confirm\u00e9e par imagerie ou bas\u00e9e sur l\u2019examen physique. Le statut de performance selon l\u2019ECOG doit demeurer \u00e0 0 ou 1. Les autorisations subs\u00e9quentes sont pour des dur\u00e9es de 4 mois.<\/p>\n<p>Les autorisations sont donn\u00e9es \u00e0 raison d\u2019une dose maximale quotidienne de 60 mg pendant 21 jours cons\u00e9cutifs par cycle de 28 jours.<\/p>\n<p><a href=\"http:\/\/www.ramq.gouv.qc.ca\/SiteCollectionDocuments\/liste_med\/liste_med_2017_07_19_fr.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.ramq.gouv.qc.ca\/SiteCollectionDocuments\/liste_med\/liste_med_2017_07_19_fr.pdf<\/a><br \/>\nAnnexe IV &#8211; page 19<\/p>\n","protected":false},"excerpt":{"rendered":"<p>COBIM\u00c9TINIB : -en association avec le v\u00e9muraf\u00e9nib, pour le traitement de premi\u00e8re intention ou de deuxi\u00e8me intention \u00e0 la suite d\u2019un \u00e9chec \u00e0 une chimioth\u00e9rapie cytotoxique ou \u00e0 une immunoth\u00e9rapie ciblant le<\/p>\n","protected":false},"author":2,"featured_media":6177,"comment_status":"closed","ping_status":"closed","template":"","tags":[],"news-category":[],"class_list":["post-6179","news","type-news","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - 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