Mantle cell lymphoma is an aggressive type of B-cell lymphoma that most frequently affects men over 50 years of age. It accounts for approximately two to 10 percent of all NHL cases. This aggressive tumour may spread to different organs in the body, including the bone marrow, stomach, spleen, and liver. It is usually treated with combination chemotherapy, alone or with the addition of targeted therapy with the monoclonal antibody, rituximab.
Signs and symptoms of this disease might include fever, night sweats, enlarged lymph nodes, fatigue, splenomegaly (enlarged spleen), hepatomegaly (enlarged liver), and weight loss.
Mantle cell lymphoma is usually diagnosed in its later stages, when it has already spread to other organs. Treatment is typically successful in the early stages, but frequent relapses are common.