Breast Density

Special thanks to Dense Breasts Canada for providing this section.


26,000 Canadian women are diagnosed annually with breast cancer, but not all cancers are found early. Mammography has reduced mortality by 40%, but is limited in women with dense breasts. What can be done to find cancer earlier in these women? Dense Breasts Canada discusses the importance of knowing and understanding your breast density.

What is breast density?

  • Every woman has fat and breast tissue in her breasts. Breast density relates to the proportion of breast tissue to fat. There are four categories of breast density that range from 0%-100%. Breasts that have more than 50% breast tissue are considered ”dense breasts” (Category C and D).
Category Percentage of dense tissue Description Percentage of women in this category
A <25% Almost Entirely Fatty ~10%
B 25-50% Scattered Areas of Density ~40%
C 51-75% Heterogeneously Dense ~40%
D >75% Extremely Dense ~10%

4 Categories of Breast Density
 

 

How common are dense breasts? 

  • Dense breasts are normal and common. 43% of women over age 40 have dense breasts (Sprague et al., 2014).
  • Having dense breasts does not mean you will develop cancer.

How is breast density determined?

  • Breast density is determined by the radiologist when viewing a mammogram. Some provinces are beginning to use breast density assessment software.
  • Breast density cannot be determined by breast size or touch. Lumpy breasts are not the same as dense breasts.  Both fatty and dense breasts can feel soft, firm or lumpy.

 

5 reasons why breast density matters

  1. Mammogram accuracy can be impacted by dense breast tissue
  • Dense breasts are the number one reason for cancer being missed by mammography. A mammogram can be assessed as “normal” or “negative,” even when there is a cancer.
  • Both cancer and dense tissue show up white on a mammogram, creating a camouflage effect and making it hard for radiologists to detect cancer.
  • In women with the highest category of density (over 75% dense tissue), mammograms are only 50% accurate, meaning 1 in 2 cancers will be missed (Kolb et al., 2012).
  1. Women with dense breasts have an increased risk of breast cancer
  • Dense breasts are an independent risk factor for breast cancer.
  • The higher the density, the higher the risk of cancer.
  • Cancer is 4-6 times more likely in women in the highest category of density than in the fatty category (Boyd et al., 2007).
  1. Dense breasts pose a greater risk than family history
  • Recent research findings show that dense breasts are an even greater risk factor than having a family history of breast cancer (Engmann et al., 2017).

 

  1. Higher risk of an interval cancer
  • Women with the highest category of density are 18 times more likely to have an interval cancer – a cancer that becomes “feelable” after a normal mammogram result and is detected in between screenings (Boyd et al., 2007).
  • Interval cancers are larger, more aggressive and have a worse prognosis than mammogram-detected cancers. Tumour stage at diagnosis influences overall survival rate and therefore diagnosis of breast cancer at an early stage is critical. (Saadatman et al., 2015)
  1. Higher risk of cancer in the other breast
  • Women who have been diagnosed with breast cancer and have dense breasts are nearly twice as likely to develop cancer in the opposite breast as women with non-dense breasts (Raghavendra et al., 2017).

Factors that can affect breast density

  • Age: Women under age 50 have the highest degree of density.
  • Menopause: Density usually decreases after menopause, but not always.
  • Ethnicity: Women of Asian descent usually have a higher level of density.
  • Heredity: Breast density can be inherited.
  • Hormone Therapy: Density increases in women on hormones (usually prescribed to manage menopausal symptoms).
  • Aromatase Inhibitors and Tamoxifen: Prescribed for breast cancer. Decreases density.

(Hashemi et al., 2017)

How can I find out my breast density?

  • Women need to take steps on their own to find out their density as they are not routinely informed. In some provinces, this information is not even relayed to the GP.  The way to find out one’s breast density varies by province.
  • In ON, AB, NB, QC, PEI, women can ask the family doctor, “What does my mammogram report say about my density?” In most cases, the information is in the report.
  •  In BC, MB, NS, this information is not shared with the family doctor. Women must submit a request for their records to the screening program.
  • In SK, NL, MB, YT, NWT, even when a request for records is submitted, only women in Category D (over 75%) can find out. There is no information recorded for women in Category C.
  • Further details on how to find out your density are found at densebreastscanada.ca.

What should I do if I have dense breasts? 

  • Speak with your doctor about your density and the associated risks, any additional risk factors, and the best screening options for you.
  • Perform regular self-exams between screenings.
  • To improve early cancer detection in dense breasts, consider additional screening, such as ultrasound and/or MRI.
  • Consider the modification of lifestyle factors such as diet, moderate exercise, decreased alcohol intake and decreased hormone use to decrease cancer risk.
  • Continue having mammograms because they can detect calcifications, which can be the earliest sign of cancer.
  • If you are diagnosed with breast cancer, consider MRI to ensure no additional tumours are hidden before deciding on lumpectomy vs. mastectomy.

Research suggests supplemental screening

  • Supplemental screening, such as ultrasound, can increase detection of early stage cancer obscured by dense breast tissue.
  • Ultrasound finds an addition al 3-4 cancers per 1000 women screened. These are cancers not detected by mammogram. Ultrasound finds cancers small and node negative, reducing the need for aggressive treatment and improving rates of survival (Berg et al., 2008).
  • Early detection of cancer is critical for less invasive treatment and improved outcomes.

Until there’s a cure, find it small.

 


Dense Breasts Canada is a nonprofit organization made up of breast cancer survivors and healthcare professionals dedicated to informing women of the risks associated with dense breast tissue.

Further information

Dense Breasts Canada   www.densebreastscanada.ca 

https://www.youtube.com/watch?v=r4MzzpWHe8g&feature=youtu.be

Physician’s Resource: densebreast-info.org

References

Berg, W., Blume, J., Cormack, J. et al. (2008). Combined screening with ultrasound and mammography vs. mammography alone in women at elevated risk of breast cancer. JAMA, 299: 2151-63.  http://www.ncbi.nlm.nih.gov/pubmed/18477782

Boyd, N., Guo, H., Martin, L., Sun, L., Stone, J., Fishel, E., Jong, R., Hislop, G., Chiarelli, A., Minkin, S., and Yaffe, M.  (2007, Jan.). Mammographic density and the risk and detection of breast cancer. New England Journal of Medicine, 356:227-236.  http://www.nejm.org/doi/full/10.1056/NEJMoa062790#t=article

Boyd, N., Martin, L.,  Yaffe, M and Minkin, S. (2011).Mammographic density and breast cancer risk: Current understanding and future prospects Breast Cancer Res 13:223 https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr2942

Engmann N., Golmakani M, Miglioretti D, Sprague, B., Kerlikowske, K., for the Breast Cancer Surveillance Consortium. (2017, Feb 2.) Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer. JAMA Oncol.  http://jamanetwork.com/journals/jamaoncology/article-abstract/2599991

Hashemi, E., Haghighat, S., Olfatbakhsh, A., Harunda,T. (2017). Investigating the Factors Affecting the Mammographic Density of Breast Tissue in Patients Referred to the Breast Cancer Research Center, Iran. Multidisciplinary Cancer Investigation. http://mcijournal.com/article-1-55-en.pdf

Kolb, T., Lichy, J., & Newhouse, J. (2002). Comparison of the performance of screening mammography, physical examination, and breast US and evaluation of factors that influence them: an analysis of 27,825 patient evaluations. Radiology. (225):165–17. http://www.surgery.usc.edu/uppergi-general/downloads/readinglist/2002-10-comparison-of-performance-screening-mammography.pdf

Raghavendra, A., Sinha, A. K., Le-Petross, H. T., Garg, N., Hsu, L., Patangan, M., Bevers, T. B., Shen, Y., Banu, A., Tripathy, D., Bedrosian, I. and Barcenas, C. H. (2017). Mammographic breast density is associated with the development of contralateral breast cancer. Cancer, 123: 1935–1940. https://www.ncbi.nlm.nih.gov/pubmed/28135395

Saadatmand, S.,Bretveld,R., Siesling,S., Tilanus-Linthorst,M. (2015, Oct. 6). Influence of tumor stage at breast cancer detection on survival in modern times:population based study in 173787 patients. The BMJ. http://www.bmj.com/content/351/bmj.h4901

Sprague, B., Gangnon, R., Burt, V., Trentham-Dietz, A., Hampton, J., Wellman, R., Miglioretti, D. (2014). Prevalence of Mammographically Dense Breasts in the United States. JNCI Journal of the National Cancer Institute, 106 (10), https://www.ncbi.nlm.nih.gov/pubmed/25217577